Police said information suggests that a Dodge van was struck by an unidentified tractor-trailer on the right side as they were traveling north on I-81 near mile marker 47 Monday just after noon.
After impact, the van traveled across the grass median and then struck an embankment.
Nine people were in the van at the time - three adults and six children. Police identified the driver as Marsha Nyla Charles Lynch, 42, Dallas, Ga., and the two adult passengers as Ronald Paul Chin, 43, Dallas, Ga., and Roan Lynch, 22, Dallas, Ga.
All nine suffered injures, but the extent of the injuries is unknown at this time, police said.
The crash remains under investigation. Anyone who may have information is asked to contact police at 717-249-2121.